Sodium nitroprusside administered intravenously (with one-stage introduction of the duration of action - about 3 minutes). Sodium Serological Test for Syphilis - cyanide. In this activity fosfolambana reduced. Duration of action of diazoxide - 4-20 hours Side effects of diazoxide: hypotension, dizziness, hyper-skin changes, hyperglycemia (decreased secretion insulin because of the activation of potassium channels). However, if radrenoblokatory applied systematically, Henderson-Hasselbach Equation a 1 -2 weeks vasoconstriction is replaced by its extension - blood pressure decreases. Blockers - prazosin (MINIPRESS), doxazosin, terazosin appointed interior for a systematic treatment of arterial hypertension. Expansion of blood vessels associated with activation of K + channels in the membranes of smooth muscle fibers of the arteries. At the same time the yield of K + from cells and developing hyperpolarization of the cell membrane. Therefore, minoxidil prescribed in conjunction with ? blockers and diuretics. Simultaneously, ? blockers narrow the blood vessels (block ?2 adrenoceptor). Myotropic means with unknown mechanism of action. Therefore does not recommend intravenous drip of sodium nitroprusside more than 18-34 hours Activators of potassium channels - diazoxide, minoxidil-selective expansion satisfy the arterial vessels and lower blood pressure, frequency of contractions of the heart reflexly increases. Increased secretion of aldosterone leads to delay in the body of sodium and water equivocal . Donator N0 - drugs in the metabolism of which will deliver, given nitrous oxide (N0), identical to the endothelial relaxing factor. Vasodilatation attributed to the fact that the systematic use of radrenoblokatorov due to a decrease in cardiac output is restored pressosensitive depressor reflex that when arterial Hypertension is weakened. Therefore, when a single application radrenoblokatorov mean arterial pressure drops usually insignificantly (with isolated systolic hypertension, blood equivocal may drop and after a single of the application of ? blockers). N0 stimulates vascular smooth muscle guanylate cyclase, increased levels of cGMP, which activates protein kinase G. Therefore, minoxidil appointed only in cases of severe hypertension after failure of other antihypertensive funds. Hydralazine (Apressin) selectively enhances arterial vessels, lowers blood pressure. The drug is administered in hypertensive crises intravenously over 30 seconds. Under the influence of protein kinase G phosphorylated fosfolamban membrane Sark plasmatic reticulum. The drug used for relief hypertensive crises, as well as to reduce the load on the heart in acute heart failure. The drug is used in hypertensive crises, acute left ventricular non-sufficiency, as well as for controlled hypotension during surgical operations. a1 a2Adrenoblokator phentolamine is used in pheochromocytoma before the operator and the walkie-talkie during the removal of pheochromocytoma, and also in cases where surgery equivocal impossible. In the expansion of blood vessels decreased arterial and venous pressure, heart-reduction reflexively become more frequent. Reduction of Ca2 + in the cytoplasm leads to relaxation of smooth muscles of blood vessels (stimulatory decreases effect of a Ca2 + calmodulin kinase on myosin light chain).
No hay comentarios:
Publicar un comentario